At the end of VN's novel Ada (1969) Dr Lagosse makes Van and Ada the last merciful injection of morphine:
Was it time for the morphine? No, not yet. Time-and-pain had not been mentioned in the Texture. Pity, since an element of pure time enters into pain, into the thick, steady, solid duration of I-can’t-bear-it pain; nothing gray-gauzy about it, solid as a black bole, I can’t, oh, call Lagosse.